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Registro Completo |
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
05/01/2016 |
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Data da última atualização: |
04/02/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CUNICO, M. M.; TREBIEN, H. A.; GALETTI, F. C.; MIGUEL, O. G.; MIGUEL, M. D.; AUER, C. G.; SILVA, C. L.; SOUZA, A. O. de. |
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Afiliação: |
MIRIAM M. CUNICO, UFPR; HERBERT A. TREBIEN, UFPR; FÁBIO C. GALETTI, USP; OBDULIO G. MIGUEL, UFPR; MARILIS D. MIGUEL, UFPR; CELSO GARCIA AUER, CNPF; CÉLIO L. SILVA, USP; ANA OLÍVIA DE SOUZA, Instituto Butantan. |
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Título: |
Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae). |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Anais da Academia Brasileira de Ciências, v. 87, n. 4, p. 1991-2000, 2015. |
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DOI: |
http://dx.doi.org/10.1590/0001-3765201520140090 |
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Idioma: |
Inglês |
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Conteúdo: |
Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/ kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924. EE, HF, DF, and piperovatine showed a potential antimycobacterial effect with MICs of 16.0, 62.0, 62.0 and 8.0 ?g/mL, respectively. Piperovatine was more effective than the EE or the other fractions. The selectivity index (SI=IC50/MIC) values calculated for EE, HF, DF and piperovatine based on the MICs and the cytotoxicity against J774 macrophages (IC50 by MTT assay) revealed values of 6.43, 2.34, 1.5 and 9.66, respectively. |
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Palavras-Chave: |
Analgesic; Analgésico; Anesthetic; Antimicobacterial; Antimycobacterial; Ottonia martiana; Piperovatina; Piperovatine; Toxicidade. |
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Thesagro: |
Anestésico; Espécie Nativa. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/136578/1/2015-Celso-AABC-Investigation.pdf
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Marc: |
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008 2015 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.1590/0001-3765201520140090$2DOI
100 1 $aCUNICO, M. M.
245 $aInvestigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae).$h[electronic resource]
260 $c2015
520 $aOttonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/ kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924. EE, HF, DF, and piperovatine showed a potential antimycobacterial effect with MICs of 16.0, 62.0, 62.0 and 8.0 ?g/mL, respectively. Piperovatine was more effective than the EE or the other fractions. The selectivity index (SI=IC50/MIC) values calculated for EE, HF, DF and piperovatine based on the MICs and the cytotoxicity against J774 macrophages (IC50 by MTT assay) revealed values of 6.43, 2.34, 1.5 and 9.66, respectively.
650 $aAnestésico
650 $aEspécie Nativa
653 $aAnalgesic
653 $aAnalgésico
653 $aAnesthetic
653 $aAntimicobacterial
653 $aAntimycobacterial
653 $aOttonia martiana
653 $aPiperovatina
653 $aPiperovatine
653 $aToxicidade
700 1 $aTREBIEN, H. A.
700 1 $aGALETTI, F. C.
700 1 $aMIGUEL, O. G.
700 1 $aMIGUEL, M. D.
700 1 $aAUER, C. G.
700 1 $aSILVA, C. L.
700 1 $aSOUZA, A. O. de
773 $tAnais da Academia Brasileira de Ciências$gv. 87, n. 4, p. 1991-2000, 2015.
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Registro original: |
Embrapa Florestas (CNPF) |
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| 1. |  | GOUVEIA, D. M.; RUSCHEL, A. R.; MACHADO, H. B.; SOARES, M. H. M. Análise da dinâmica de crescimento em espécies florestais por grupo ecológico na Flona do Tapajós. In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA AMAZÔNIA ORIENTAL, 15., 2011, Belém, PA. A ciência de fazer ciência: anais. Belém, PA: Embrapa Amazônia Oriental, 2011. 1 CD-ROM. PIBIC-2011.| Tipo: Artigo em Anais de Congresso |
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